Applicable for:

Anchorage independent cell suspension culture

Anchorage dependent cell culture

Fixed-Fluidized bed culture of fibra disk

Suspension culture of fibra disk

Summary:

The cell culture system of 1L-5L bioreactor is composed of 3-6 units of 1L bioreactors that are able to operate independently. It is mainly used in small scale , continuous or discontinuous microorganism or cell culture to compare parameters of multi-processes in the phase of bioprocess exploitation and process optimizing. Relative to shake-flask culture, it is able to test online and control process parameters, such as temperature, pH, dissolved oxygen, aeration and agitation speed. Also the bioreactor has sampling devices that are safe and convenient, which is able to analyze and compare data outside. The monitoring system is able to record and observe the 1L-5L bio-reactor and adjust parameters during the process of culture.

Main feature:

1. Control system

Capable of precise control of temperature, pH, dissolved oxygen, surface aeration, deep aeration and agitation speed.

2. Driver element

The standard agitator shaft adopts rotate mechanical seal, which avoids contamination.

3. Temperature control module

The vessel adopts heating carpet to control temperature. The tail gas is discharged after heated by the carpet as well. It can effectively reduce the range of temperature flection and improve control precision.

4. Peristaltic pump module

The glucose, alkali, nutrion and anti-foam can be fed automatically according to the required culture process, and can be fed manually.

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Fibra disk bioreactor, also known as basket bioreactor, is applied to anchorage dependent cell culture of animal cell, inset cell, etc.. Successfully cases of this product include vero cell of rabies vaccine, vero cell of IPV, MDCK cell of bird flu, BSR cell of rabies vaccine of veterinary use, CHO cell of EPO, vero cell of nephritic syndrome, vero cell of swine fever, vero cell of BVDV, diploid cells of rabies vaccine.

Stainless steel bioreactor

The stainless steel bioreactor adopts modular design and is customized according to user's requirements. It is capable of CIP, SIP, auto-lift of lid, cold point monitor of sterilization, data storage and remote monitor, etc. When cultured in fixed-fluidized bed, cells enter polyester disc, eliminate damage from impeller's shear force and reduce the foam influence from gas sparger, which makes cells stay in a relative static state and prevent cells from shedding easily. Long maintenance time greatly increases harvesting and decreases the DNA content of host cell in harvest solution.

Application

● Batch, feeding or continuous perfusion culture of anchorage dependent cells such as animal cells, insect cells, etc. Mainly applied in cell secretory products, such as genetic recombinant protein and virus, etc.

● Pilot scale sample preparation and industrial scale production.

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The unique design of Ritai microcarrier bioreactor makes anchorage dependent cell easier to adhere to microcarriers, which greatly reduces cost when achieving maximal output. This bioreactor is applicable for anchorage dependent cell culture of animal and plant. BHK/BSR, VERO, CHO, MDCK, 293, MARK145,PK15 cells have been successfully cultured.

Stainless steel bioreactor:

The stainless steel bioreactor adopts modular design and customizes according to user's requirements. It is capable of CIP, SIP, auto-lift of lid, cold point monitor of sterilization, data storage and remote monitor, etc. The low shear force of this bioreactor realizes high density and large scale cell culture. The culture density of microcarrier reaches up to 20g/L, and the cell density reaches up to 1.5*107.Volume is from 20L to 5000L.

Application：

1. Batch, feeding or continuous perfusion culture of insect, plant, mammalian cell.

2. Microcarrier culture of anchorage dependent cell, suspension culture of anchorage independent cell.

3. Amplification of cell seed.

4. Pilot scale sample preparation and industrial scale production.

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Shanghai Ritai is a manufacturer of integrated cell culture equipment and services for different scales of cell culture in bio-pharmaceuticals and mass production.

Stainless steel bioreactor:

By modular design, our stainless steel bioreactor can provide various function from general to comprehensive. This system provides thorough solution for different kinds of budgets and requirements. In addition, by advanced pressure vessel manufacture process and function, it meets most requirements of today’s bio-pharmaceuticals. The culture volume is 20L to 5000L. BHK/BSR, VERO, CHO, DMCK, 293, MARK145 cells have been successfully cultured.

Application:

1. Suspension cultures of microorganisms and cells

2. Developing and optimizing of cell culture process

3. Seed amplification

4. Mass production

Please visit Alibaba: https://ritaichina.en.alibaba.com for more technical details!